GUAIFENESIN USP
GUAIFENESIN USP
GUAIFENESIN USP
Molecular Formula: C10H14O4
Molecular Weight : 198.2
CAS No. : [93–14–1]
Application:
Expectorant.
General properties:
White crystals or crystalline powder.
SPECIFICATION FOR CHLORPHENESIN BP
| Sr. No. | Tests | Specification |
|---|---|---|
| 1 | DESCRIPTION | White to slightly gray, crystalline powder, may have a slight characteristic odour. |
| 2 | SOLUBILITY | Soluble in water, in alcohol, in chloroform & in propylene glycol, sparingly soluble in glycerin. |
| 3 | IDENTIFICATION A) IR B) UV | The Infra-Red spectrum of the sample is concordant with that of Guaifenesin WS. The ultraviolet absorption spectrum of 0.004% w/v test solution & WS solution are examined spectrophotometrically in 1 cm cells, over a spectral range from 200 to 400 nm., exhibits the maxima and graph is concordant. |
| 4 | ORGANIC IMPURITIES 1) GUAIFENESIN β-ISOMER 2) GUAIACOL 3) ANY INDIVIDUAL UNSPECIFIED IMPURITY 4) TOTAL IMPURITIES | Not more than 1.5% Not more than 0.03% Not more than 0.5% Not more than 1.0% |
| 5 | LOSS ON DRYING | Not more than 0.5% |
| 6 | ASSAY (BY HPLC) (On Dried Basis) | ASSAY (BY HPLC) (On Dried Basis) |